[Pulmonary hemorrhage associated with celiac disease].
Identifieur interne : 001292 ( Main/Exploration ); précédent : 001291; suivant : 001293[Pulmonary hemorrhage associated with celiac disease].
Auteurs : María Eugenia Testa [Argentine] ; Alberto Maffey ; Alejandro Colom ; Luis Agüero ; Ignacio Rogé ; María Sol Andrewartha ; Alejandro TeperSource :
- Archivos argentinos de pediatria [ 1668-3501 ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Hémorragie, Hémosidérose, Maladie coeliaque, Maladies pulmonaires.
- étiologie : Anémie par carence en fer, Hémoptysie.
- Adolescent, Humains, Mâle, Syndrome.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Celiac Disease, Hemorrhage, Hemosiderosis, Lung Diseases.
- etiology : Anemia, Iron-Deficiency, Hemoptysis.
- Adolescent, Humans, Male, Syndrome.
Abstract
Idiopathic pulmonary hemosiderosis is a severe and potentially fatal disease characterized by recurrent episodes of alveolar hemorrhage, hemoptysis, and anemia. His association with celiac disease, described as Lane- Hamilton syndrome, could be due to the fact that both entities share a common pathogenic immune pathway. We report two patients of 13 years who consulted for hemoptysis and severe anemia that had not responded to immunosuppressive treatment with pulses of methyl prednisolone, oral meprednisone and hydroxychloroquine. Although both children highlight the absence of gastrointestinal symptoms at the time of consultation, the dosage of anti-endomysial and anti-transglutaminase antibodies was positive and biopsy confirmed the presence of intestinal enteropathy. It is emphasized that in patients with diffuse alveolar hemorrhage, even in the absence of gastrointestinal symptoms, the concomitant presence of celiac disease should be evaluated. If celiac disease is present, the incorporation of a gluten-free diet helps to control the symptoms, allows reducing the immunosuppressive treatment and improves the clinical course of both entities.
DOI: 10.5546/aap.2012.e72
PubMed: 22859336
Affiliations:
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Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Centro Respiratorio, Hospital de Niños Dr. Ricardo Gutiérrez, Ciudad autónoma de Buenos Aires</wicri:regionArea><wicri:noRegion>Ciudad autónoma de Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Maffey, Alberto" sort="Maffey, Alberto" uniqKey="Maffey A" first="Alberto" last="Maffey">Alberto Maffey</name></author><author><name sortKey="Colom, Alejandro" sort="Colom, Alejandro" uniqKey="Colom A" first="Alejandro" last="Colom">Alejandro Colom</name></author><author><name sortKey="Aguero, Luis" sort="Aguero, Luis" uniqKey="Aguero L" first="Luis" last="Agüero">Luis Agüero</name></author><author><name sortKey="Roge, Ignacio" sort="Roge, Ignacio" uniqKey="Roge I" first="Ignacio" last="Rogé">Ignacio Rogé</name></author><author><name sortKey="Andrewartha, Maria Sol" sort="Andrewartha, Maria Sol" uniqKey="Andrewartha M" first="María Sol" last="Andrewartha">María Sol Andrewartha</name></author><author><name sortKey="Teper, Alejandro" sort="Teper, Alejandro" uniqKey="Teper A" first="Alejandro" last="Teper">Alejandro Teper</name></author></analytic><series><title level="j">Archivos argentinos de pediatria</title><idno type="eISSN">1668-3501</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Anemia, Iron-Deficiency (etiology)</term><term>Celiac Disease (diagnosis)</term><term>Hemoptysis (etiology)</term><term>Hemorrhage (diagnosis)</term><term>Hemosiderosis (diagnosis)</term><term>Humans</term><term>Lung Diseases (diagnosis)</term><term>Male</term><term>Syndrome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Anémie par carence en fer (étiologie)</term><term>Humains</term><term>Hémoptysie (étiologie)</term><term>Hémorragie (diagnostic)</term><term>Hémosidérose (diagnostic)</term><term>Maladie coeliaque (diagnostic)</term><term>Maladies pulmonaires (diagnostic)</term><term>Mâle</term><term>Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Celiac Disease</term><term>Hemorrhage</term><term>Hemosiderosis</term><term>Lung Diseases</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Hémorragie</term><term>Hémosidérose</term><term>Maladie coeliaque</term><term>Maladies pulmonaires</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Anemia, Iron-Deficiency</term><term>Hemoptysis</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Anémie par carence en fer</term><term>Hémoptysie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Humans</term><term>Male</term><term>Syndrome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Humains</term><term>Mâle</term><term>Syndrome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Idiopathic pulmonary hemosiderosis is a severe and potentially fatal disease characterized by recurrent episodes of alveolar hemorrhage, hemoptysis, and anemia. His association with celiac disease, described as Lane- Hamilton syndrome, could be due to the fact that both entities share a common pathogenic immune pathway. We report two patients of 13 years who consulted for hemoptysis and severe anemia that had not responded to immunosuppressive treatment with pulses of methyl prednisolone, oral meprednisone and hydroxychloroquine. Although both children highlight the absence of gastrointestinal symptoms at the time of consultation, the dosage of anti-endomysial and anti-transglutaminase antibodies was positive and biopsy confirmed the presence of intestinal enteropathy. It is emphasized that in patients with diffuse alveolar hemorrhage, even in the absence of gastrointestinal symptoms, the concomitant presence of celiac disease should be evaluated. If celiac disease is present, the incorporation of a gluten-free diet helps to control the symptoms, allows reducing the immunosuppressive treatment and improves the clinical course of both entities.</div></front></TEI><affiliations><list><country><li>Argentine</li></country></list><tree><noCountry><name sortKey="Aguero, Luis" sort="Aguero, Luis" uniqKey="Aguero L" first="Luis" last="Agüero">Luis Agüero</name><name sortKey="Andrewartha, Maria Sol" sort="Andrewartha, Maria Sol" uniqKey="Andrewartha M" first="María Sol" last="Andrewartha">María Sol Andrewartha</name><name sortKey="Colom, Alejandro" sort="Colom, Alejandro" uniqKey="Colom A" first="Alejandro" last="Colom">Alejandro Colom</name><name sortKey="Maffey, Alberto" sort="Maffey, Alberto" uniqKey="Maffey A" first="Alberto" last="Maffey">Alberto Maffey</name><name sortKey="Roge, Ignacio" sort="Roge, Ignacio" uniqKey="Roge I" first="Ignacio" last="Rogé">Ignacio Rogé</name><name sortKey="Teper, Alejandro" sort="Teper, Alejandro" uniqKey="Teper A" first="Alejandro" last="Teper">Alejandro Teper</name></noCountry><country name="Argentine"><noRegion><name sortKey="Testa, Maria Eugenia" sort="Testa, Maria Eugenia" uniqKey="Testa M" first="María Eugenia" last="Testa">María Eugenia Testa</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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